A 28-year-old man from Hanley has been arrested on suspicion of assault causing actual bodily harm.
Officers were called to Tontine Street in Hanley at 10.10pm on Saturday, 8 February to reports that a man was causing a disturbance.
On attendance a man, who had been detained by several other men on the scene, was arrested. One of the men who detained the arrested man became ill shortly afterwards and attended hospital where he sadly died.
The arrested man remains in custody at this time while investigations continue.
Anyone with any information should message Staffordshire Police on Facebook or Twitter quoting incident number 817 of 8 February, call 101 or alternatively contact Crimestoppers anonymously on 0800 555 111.